Action potential repolarization enabled by Ca++ channel deactivation in PSpice simulation of smooth muscle propagation
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چکیده
منابع مشابه
Action potential repolarization enabled by Ca++ channel deactivation in PSpice simulation of smooth muscle propagation
BACKGROUND Previously, only the rising phase of the action potential (AP) in cardiac muscle and smooth muscle could be simulated due to the instability of PSpice upon insertion of a second black box (BB) into the K+ leg of the basic membrane unit. This restriction was acceptable because only the transmission of excitation from one cell to the next was investigated. METHODS In the current work...
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BACKGROUND We previously examined transverse propagation of action potentials between 2 and 3 parallel chain of cardiac muscle cells (CMC) simulated using the PSpice program. The present study was done to examine transverse propagation between 5 parallel chains in an expanded model of CMC and smooth muscle cells (SMC). METHODS Excitation was transmitted from cell to cell along a strand of 5 c...
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It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...
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It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...
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ژورنال
عنوان ژورنال: BioMedical Engineering OnLine
سال: 2005
ISSN: 1475-925X
DOI: 10.1186/1475-925x-4-71